Short answer: The Accord is a long-haul champion — well-maintained examples routinely pass 200k miles, so the decision is usually about you, not the car.
Honda Accord
Typical car
Typical lifespan
200k+ mi
150k–200k mi
Reliability
Excellent
Average
Watch item
Older automatics
Varies
The Accord is one of the most durable mainstream cars ever built, and a maintained one clearing 200,000 miles is ordinary rather than remarkable. That flips the replace question: you're rarely forced out by the car dying, so it comes down to whether you want newer features or lower risk.
The main historical caveat is the automatic transmission on some older V6 generations. On a high-mileage example, that's the repair that can tip an otherwise-sound Accord into replace territory — otherwise, keep driving it.
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The numbers above are model-specific; the full method — the warning signs, the costs, and when planned beats emergency — is in the when should you replace your car guide.